/* ============================================================
   H9N2 Tracker — 実験ノート／機器読み出しをモチーフにした配色
   数値・日付・アミノ酸表記はすべて等幅（IBM Plex Mono, tabular）
   ============================================================ */

:root {
  --ink:        #0F1620;
  --ink-2:      #1C2733;
  --paper:      #FFFFFF;
  --paper-2:    #F4F6F8;
  --paper-3:    #E9EDF1;
  --rule:       #D3DAE1;
  --rule-soft:  #E6EAEF;
  --text:       #16202B;
  --text-2:     #4C5B69;
  --text-3:     #78889A;

  --assay:      #0B6E77;   /* 主色：アッセイ・ティール */
  --assay-ink:  #084F56;
  --assay-wash: #E2F0F1;
  --amber:      #A65209;   /* 中等症・注意 */
  --amber-wash: #FBEDDF;
  --crimson:    #94182B;   /* 重症・死亡 */
  --crimson-wash:#F8E4E7;
  --violet:     #4F4189;   /* 分子・ゲノム */
  --violet-wash:#EBE8F5;
  --moss:       #3D6B3A;   /* 軽症・回復 */
  --moss-wash:  #E6EFE4;

  --grid:       rgba(15,22,32,.055);
  --shadow:     0 1px 2px rgba(15,22,32,.05), 0 8px 24px -16px rgba(15,22,32,.28);

  --mono: "IBM Plex Mono", ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  --sans: "Zen Kaku Gothic New", "Hiragino Sans", "Noto Sans JP", system-ui, -apple-system, sans-serif;

  --rail: 15.5rem;
  --maxw: 82rem;
}

@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --ink:#070B10; --ink-2:#0E151E;
    --paper:#111A24; --paper-2:#0C141C; --paper-3:#18232F;
    --rule:#27343F; --rule-soft:#1C2833;
    --text:#DDE5EC; --text-2:#9DAEBD; --text-3:#71828F;
    --assay:#3FB4BC; --assay-ink:#7FD3D8; --assay-wash:#0E2B2E;
    --amber:#E09144; --amber-wash:#2F2011;
    --crimson:#E4708A; --crimson-wash:#31131A;
    --violet:#A497E3; --violet-wash:#1D1935;
    --moss:#7CB574; --moss-wash:#16240F;
    --grid: rgba(221,229,236,.05);
    --shadow: 0 1px 2px rgba(0,0,0,.4), 0 10px 30px -18px rgba(0,0,0,.9);
  }
}
:root[data-theme="dark"] {
  --ink:#070B10; --ink-2:#0E151E;
  --paper:#111A24; --paper-2:#0C141C; --paper-3:#18232F;
  --rule:#27343F; --rule-soft:#1C2833;
  --text:#DDE5EC; --text-2:#9DAEBD; --text-3:#71828F;
  --assay:#3FB4BC; --assay-ink:#7FD3D8; --assay-wash:#0E2B2E;
  --amber:#E09144; --amber-wash:#2F2011;
  --crimson:#E4708A; --crimson-wash:#31131A;
  --violet:#A497E3; --violet-wash:#1D1935;
  --moss:#7CB574; --moss-wash:#16240F;
  --grid: rgba(221,229,236,.05);
  --shadow: 0 1px 2px rgba(0,0,0,.4), 0 10px 30px -18px rgba(0,0,0,.9);
}

*, *::before, *::after { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0; background: var(--paper-2); color: var(--text);
  font-family: var(--sans); font-size: 15px; line-height: 1.75;
  font-feature-settings: "palt" 1;
}
h1,h2,h3,h4 { font-weight: 700; line-height: 1.35; letter-spacing: .01em; margin: 0; }
p { margin: 0 0 1em; }
a { color: var(--assay); text-decoration-thickness: 1px; text-underline-offset: .18em; }
a:hover { color: var(--assay-ink); }
:focus-visible { outline: 2px solid var(--assay); outline-offset: 2px; border-radius: 2px; }
code, .mono, .num { font-family: var(--mono); font-variant-numeric: tabular-nums; }

/* ---------- masthead : 機器の読み出しパネル ---------- */
.mast { background: var(--ink); color: #E7EDF3; border-bottom: 1px solid var(--ink-2); }
.mast-in { max-width: var(--maxw); margin: 0 auto; padding: .85rem 1.5rem; display: flex; gap: 1.25rem; align-items: baseline; flex-wrap: wrap; }
.mast-mark { font-family: var(--mono); font-weight: 600; font-size: .95rem; letter-spacing: .14em; color: #fff; text-decoration: none; white-space: nowrap; }
.mast-mark .sub { color: var(--assay-ink); }
.mast-title { font-size: .82rem; color: #93A6B6; letter-spacing: .04em; }
.readout { margin-left: auto; display: flex; gap: 1.1rem; font-family: var(--mono); font-size: .72rem; letter-spacing: .06em; color: #7E94A6; flex-wrap: wrap; }
.readout b { color: #DCE6EE; font-weight: 500; }
.readout .dot { display:inline-block; width:.42em; height:.42em; border-radius:50%; background: var(--assay-ink); margin-right:.45em; vertical-align:.08em; }

/* ---------- nav ---------- */
.nav { background: var(--ink-2); border-bottom: 1px solid var(--rule); position: sticky; top: 0; z-index: 30; }
.nav-in { max-width: var(--maxw); margin: 0 auto; padding: 0 1.5rem; display: flex; gap: .1rem; overflow-x: auto; scrollbar-width: none; }
.nav-in::-webkit-scrollbar { display: none; }
.nav a {
  font-family: var(--mono); font-size: .78rem; letter-spacing: .04em; color: #A3B5C4;
  text-decoration: none; padding: .72rem .95rem; white-space: nowrap; border-bottom: 2px solid transparent;
}
.nav a:hover { color: #fff; background: rgba(255,255,255,.045); }
.nav a[aria-current="page"] { color: #fff; border-bottom-color: var(--assay-ink); }
.nav a .idx { color: #5E7285; }

/* ---------- layout ---------- */
.wrap { max-width: var(--maxw); margin: 0 auto; padding: 2.25rem 1.5rem 5rem; }
.lede { max-width: 52rem; }
.eyebrow {
  font-family: var(--mono); font-size: .7rem; letter-spacing: .18em; text-transform: uppercase;
  color: var(--assay); margin: 0 0 .55rem; display: flex; align-items: center; gap: .6rem;
}
.eyebrow::after { content:""; flex:1; height:1px; background: var(--rule); }
h1.page { font-size: clamp(1.45rem, 2.8vw, 2.05rem); letter-spacing: -.005em; margin-bottom: .8rem; max-width: 30ch; }
.sub { color: var(--text-2); font-size: .95rem; }

section { margin-top: 3rem; }
h2.sec { font-size: 1.18rem; margin-bottom: .35rem; }
h2.sec + .sub { margin-bottom: 1.15rem; }

/* ---------- panel ---------- */
.panel { background: var(--paper); border: 1px solid var(--rule); border-radius: 3px; box-shadow: var(--shadow); }
.panel-h { padding: .8rem 1.1rem; border-bottom: 1px solid var(--rule-soft); display: flex; align-items: baseline; gap: .8rem; flex-wrap: wrap; }
.panel-h h3 { font-size: .92rem; }
.panel-h .hint { font-family: var(--mono); font-size: .7rem; color: var(--text-3); letter-spacing: .05em; margin-left: auto; }
.panel-b { padding: 1.1rem; }
.graph { background-image: linear-gradient(var(--grid) 1px, transparent 1px), linear-gradient(90deg, var(--grid) 1px, transparent 1px); background-size: 12px 12px; }

/* ---------- stat strip ---------- */
.stats { display: grid; grid-template-columns: repeat(auto-fit, minmax(9.5rem, 1fr)); border: 1px solid var(--rule); border-radius: 3px; background: var(--paper); overflow: hidden; }
.stat { padding: .9rem 1.05rem; border-right: 1px solid var(--rule-soft); }
.stat:last-child { border-right: 0; }
.stat dt { font-family: var(--mono); font-size: .66rem; letter-spacing: .12em; text-transform: uppercase; color: var(--text-3); margin: 0 0 .3rem; }
.stat dd { margin: 0; font-family: var(--mono); font-size: 1.5rem; font-weight: 600; line-height: 1.1; font-variant-numeric: tabular-nums; }
.stat dd small { font-size: .68rem; font-weight: 400; color: var(--text-3); margin-left: .35em; letter-spacing: .04em; }

/* ---------- epicurve (signature) ---------- */
.curve { position: relative; }
.curve svg { display: block; width: 100%; height: auto; }
.curve .bar { cursor: pointer; }
.curve .bar rect { transition: opacity .12s ease; }
.curve .bar:hover rect.v { opacity: .72; }
.curve .bar.off rect.v { opacity: .22; }
.curve-legend { display: flex; gap: 1rem; flex-wrap: wrap; font-family: var(--mono); font-size: .68rem; color: var(--text-2); letter-spacing: .04em; margin-top: .7rem; }
.curve-legend i { display: inline-block; width: .72rem; height: .72rem; border-radius: 1px; margin-right: .35rem; vertical-align: -.06em; }
.tip {
  position: fixed; z-index: 60; pointer-events: none; background: var(--ink); color: #E7EDF3;
  font-family: var(--mono); font-size: .72rem; line-height: 1.55; padding: .5rem .65rem; border-radius: 3px;
  box-shadow: 0 8px 24px -8px rgba(0,0,0,.5); max-width: 20rem; opacity: 0; transition: opacity .1s;
}
.tip.on { opacity: 1; }

/* ---------- filters ---------- */
.filters { display: flex; gap: .55rem; flex-wrap: wrap; align-items: center; }
.filters label { font-family: var(--mono); font-size: .68rem; letter-spacing: .1em; text-transform: uppercase; color: var(--text-3); }
select, input[type="search"] {
  font-family: var(--mono); font-size: .8rem; color: var(--text); background: var(--paper);
  border: 1px solid var(--rule); border-radius: 2px; padding: .38rem .55rem; min-width: 7rem;
}
input[type="search"] { min-width: 13rem; }
.btn-reset {
  font-family: var(--mono); font-size: .72rem; letter-spacing: .06em; color: var(--text-2);
  background: none; border: 1px solid var(--rule); border-radius: 2px; padding: .38rem .7rem; cursor: pointer;
}
.btn-reset:hover { border-color: var(--assay); color: var(--assay); }

/* ---------- table ---------- */
.tbl-wrap { overflow-x: auto; }
table.data { width: 100%; border-collapse: collapse; font-size: .82rem; }
table.data th, table.data td { text-align: left; padding: .5rem .65rem; border-bottom: 1px solid var(--rule-soft); vertical-align: top; }
table.data thead th {
  position: sticky; top: 0; background: var(--paper); z-index: 2;
  font-family: var(--mono); font-size: .66rem; letter-spacing: .1em; text-transform: uppercase;
  color: var(--text-3); font-weight: 500; border-bottom: 1px solid var(--rule); white-space: nowrap; cursor: pointer;
}
table.data thead th:hover { color: var(--assay); }
table.data thead th .ar { opacity: .45; font-size: .8em; }
table.data tbody tr:hover { background: var(--paper-2); }
table.data td.n { font-family: var(--mono); font-variant-numeric: tabular-nums; white-space: nowrap; }
table.data td.note { color: var(--text-2); font-size: .78rem; line-height: 1.6; min-width: 18rem; }
table.data td.src { white-space: normal; min-width: 6.5rem; }
table.data td.src a { font-family: var(--mono); font-size: .68rem; display: inline-block; margin: 0 .4rem .15rem 0; }
table.data td .chip + .chip { margin-left: .3rem; }

/* ラインリスト：列ごとの折り返し方針 */
table.lines th, table.lines td { padding: .45rem .6rem; }
table.lines td:nth-child(1), table.lines td:nth-child(3), table.lines td:nth-child(4),
table.lines td:nth-child(5), table.lines td:nth-child(6), table.lines td:nth-child(7),
table.lines td:nth-child(8) { white-space: nowrap; }
table.lines td:nth-child(2) { min-width: 8.5rem; }
table.lines td.note { min-width: 18rem; max-width: 24rem; }

/* ---------- chips ---------- */
.chip {
  display: inline-block; font-family: var(--mono); font-size: .66rem; letter-spacing: .05em;
  padding: .1rem .42rem; border-radius: 2px; white-space: nowrap; border: 1px solid transparent;
}
.chip.mild     { background: var(--moss-wash);    color: var(--moss);    border-color: color-mix(in srgb, var(--moss) 30%, transparent); }
.chip.moderate { background: var(--amber-wash);   color: var(--amber);   border-color: color-mix(in srgb, var(--amber) 30%, transparent); }
.chip.severe   { background: var(--crimson-wash); color: var(--crimson); border-color: color-mix(in srgb, var(--crimson) 32%, transparent); }
.chip.died     { background: var(--crimson);      color: #fff; }
.chip.na       { background: var(--paper-3);      color: var(--text-3); }
.chip.tag      { background: var(--assay-wash);   color: var(--assay-ink); border-color: color-mix(in srgb, var(--assay) 26%, transparent); }
.chip.violet   { background: var(--violet-wash);  color: var(--violet);  border-color: color-mix(in srgb, var(--violet) 26%, transparent); }

/* ---------- genome map (mutations signature) ---------- */
.genome { display: grid; gap: .3rem; }
.seg { display: grid; grid-template-columns: 3.6rem 1fr; align-items: center; gap: .7rem; }
.seg-name { font-family: var(--mono); font-size: .74rem; font-weight: 600; color: var(--text-2); letter-spacing: .06em; text-align: right; }
.seg-track { position: relative; height: 1.6rem; background: var(--paper-3); border-radius: 2px; }
.seg-track .mk {
  position: absolute; top: 0; bottom: 0; width: 2px; background: var(--violet); cursor: pointer;
  border: 0; padding: 0;
}
.seg-track .mk::after {
  content: ""; position: absolute; left: 50%; top: 50%; width: .62rem; height: .62rem;
  transform: translate(-50%,-50%) rotate(45deg); background: var(--violet); border-radius: 1px;
}
.seg-track .mk.key::after { width: .8rem; height: .8rem; }
.seg-track .mk.on::after, .seg-track .mk:hover::after { background: var(--assay); box-shadow: 0 0 0 3px var(--assay-wash); }
.seg-track .mk.on, .seg-track .mk:hover { background: var(--assay); }

/* ---------- marker cards ---------- */
.mk-list { display: grid; gap: .8rem; }
.mk-card { background: var(--paper); border: 1px solid var(--rule); border-left: 3px solid var(--violet); border-radius: 3px; padding: 1rem 1.15rem; }
.mk-card.key { border-left-color: var(--assay); }
.mk-card.watch { border-left-color: var(--amber); }
.mk-card h3 { font-family: var(--mono); font-size: .95rem; letter-spacing: .02em; display: flex; gap: .6rem; align-items: baseline; flex-wrap: wrap; }
.mk-card .ttl { font-family: var(--sans); font-size: .93rem; font-weight: 700; margin: .45rem 0 .5rem; }
.mk-card p { font-size: .855rem; line-height: 1.85; color: var(--text); margin-bottom: .7rem; }
.mk-meta { display: flex; gap: 1.1rem; flex-wrap: wrap; font-size: .74rem; color: var(--text-2); border-top: 1px dashed var(--rule); padding-top: .6rem; }
.mk-meta b { font-family: var(--mono); font-size: .66rem; letter-spacing: .1em; text-transform: uppercase; color: var(--text-3); font-weight: 500; margin-right: .4rem; }

/* ---------- evidence ladder ---------- */
.ladder { display: grid; gap: 0; }
.rung { display: grid; grid-template-columns: 11rem 1fr; gap: 1.6rem; padding: 1.5rem 0; border-top: 1px solid var(--rule); }
.rung:first-child { border-top: 0; }
.rung-l { font-family: var(--mono); font-size: .76rem; color: var(--assay); letter-spacing: .04em; position: sticky; top: 4rem; align-self: start; }
.rung h3 { font-size: 1rem; margin-bottom: .6rem; }
.rung .find { font-size: .875rem; line-height: 1.85; }
.rung .imp { margin-top: .8rem; padding: .7rem .9rem; background: var(--assay-wash); border-radius: 2px; font-size: .84rem; line-height: 1.8; }
.rung .imp b { font-family: var(--mono); font-size: .66rem; letter-spacing: .1em; text-transform: uppercase; color: var(--assay-ink); display: block; margin-bottom: .25rem; }
.refs { margin-top: .7rem; display: flex; gap: .5rem; flex-wrap: wrap; }
.refs a { font-family: var(--mono); font-size: .68rem; color: var(--text-2); border: 1px solid var(--rule); border-radius: 2px; padding: .12rem .45rem; text-decoration: none; }
.refs a:hover { border-color: var(--assay); color: var(--assay); }

/* ---------- country cards ---------- */
.cards { display: grid; gap: .9rem; grid-template-columns: repeat(auto-fill, minmax(21rem, 1fr)); }
.card { background: var(--paper); border: 1px solid var(--rule); border-radius: 3px; padding: 1rem 1.15rem; }
.card h3 { font-size: 1rem; display: flex; align-items: baseline; gap: .55rem; flex-wrap: wrap; }
.card .iso { font-family: var(--mono); font-size: .68rem; color: var(--text-3); letter-spacing: .1em; }
.card .lin { font-family: var(--mono); font-size: .74rem; color: var(--violet); margin: .45rem 0 .55rem; }
.card p { font-size: .845rem; line-height: 1.82; color: var(--text); }

/* ---------- org list ---------- */
.org { border-top: 1px solid var(--rule); padding: 1.4rem 0; }
.org:first-child { border-top: 0; }
.org > h3 { font-size: 1.02rem; margin-bottom: .1rem; }
.org > .kind { font-family: var(--mono); font-size: .68rem; letter-spacing: .1em; color: var(--text-3); text-transform: uppercase; margin-bottom: .9rem; }
.feed { display: grid; gap: .7rem; }
.feed-item { background: var(--paper); border: 1px solid var(--rule); border-radius: 3px; padding: .8rem 1rem; }
.feed-item h4 { font-size: .89rem; margin-bottom: .3rem; }
.feed-item p { font-size: .82rem; line-height: 1.8; color: var(--text-2); margin-bottom: .5rem; }
.feed-item .fm { display: flex; gap: .8rem; align-items: center; flex-wrap: wrap; font-family: var(--mono); font-size: .68rem; color: var(--text-3); }

/* ---------- misc ---------- */
.callout { border-left: 3px solid var(--amber); background: var(--amber-wash); padding: .9rem 1.1rem; border-radius: 0 3px 3px 0; font-size: .87rem; line-height: 1.85; }
.callout b { color: var(--amber); }
ul.plain { padding-left: 1.15rem; margin: 0; }
ul.plain li { margin-bottom: .55rem; font-size: .875rem; line-height: 1.8; }
.foot { border-top: 1px solid var(--rule); margin-top: 4rem; padding: 1.6rem 0 0; font-size: .78rem; color: var(--text-3); font-family: var(--mono); line-height: 1.9; }
.count-line { font-family: var(--mono); font-size: .74rem; color: var(--text-2); letter-spacing: .04em; }
.loading { font-family: var(--mono); font-size: .8rem; color: var(--text-3); padding: 2rem 0; }

@media (max-width: 720px) {
  .wrap { padding: 1.6rem 1rem 3.5rem; }
  .mast-in { padding: .75rem 1rem; }
  .nav-in { padding: 0 1rem; }
  .rung { grid-template-columns: 1fr; gap: .5rem; }
  .rung-l { position: static; }
  .readout { width: 100%; margin-left: 0; }
}
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after { transition-duration: .01ms !important; animation-duration: .01ms !important; }
}